[HTML][HTML] Pentosan Polysulfate affords pleotropic protection to multiple cells and tissues
Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like
molecule, shares many of the interactive properties of HS. The aim of this review was to …
molecule, shares many of the interactive properties of HS. The aim of this review was to …
Pentosan polysulfate, a semisynthetic heparinoid disease-modifying osteoarthritic drug with roles in intervertebral disc repair biology emulating the stem cell …
This review highlights the attributes of pentosan polysulfate (PPS) in the promotion of
intervertebral disc (IVD) repair processes. PPS has been classified as a disease-modifying …
intervertebral disc (IVD) repair processes. PPS has been classified as a disease-modifying …
Stabilized pentosan polysulfate (PPS) formulations and methods of analyzing them
J Ellinghuysen, C Filburn, D Griffin… - US Patent App. 11 …, 2007 - Google Patents
1201 PENNSYLVANIAAVENUE, NW WASHINGTON, DC 20004-2401 (US) Various
pentosan polysulfate (PPS) formulations useful for treatment of osteoarthritis, interstitial …
pentosan polysulfate (PPS) formulations useful for treatment of osteoarthritis, interstitial …
Interactions of pentosan polysulfate with cartilage matrix proteins and synovial fibroblasts derived from patients with osteoarthritis
P Ghosh, N Hutadilok - Osteoarthritis and Cartilage, 1996 - Elsevier
Pentosan polysulfate (PPS) has been shown to improve symptoms of patients with
osteoarthritis (OA) when studied under double-blinded conditions. Laboratory studies …
osteoarthritis (OA) when studied under double-blinded conditions. Laboratory studies …
[HTML][HTML] Pentosan polysulfate binds to STRO-1+ mesenchymal progenitor cells, is internalized, and modifies gene expression: a novel approach of pre-programing …
J Wu, S Shimmon, S Paton, C Daly… - Stem Cell Research & …, 2017 - Springer
Background The pharmaceutical agent pentosan polysulfate (PPS) is known to induce
proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in …
proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in …
[HTML][HTML] Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses
EH Schuchman, Y Ge, A Lai, Y Borisov, M Faillace… - PloS one, 2013 - journals.plos.org
Background Pentosan polysulfate (PPS) is an FDA-approved, oral medication with anti-
inflammatory and pro-chondrogenic properties. We have previously shown that animal …
inflammatory and pro-chondrogenic properties. We have previously shown that animal …
The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment
P Ghosh - Seminars in arthritis and rheumatism, 1999 - Elsevier
OBJECTIVES:: Structure-modifying osteoarthritis (OA) drugs (SMOADs) may bedefined as
agents that reverse, retard, or stabilize the underlying pathology of OA, thereby providing …
agents that reverse, retard, or stabilize the underlying pathology of OA, thereby providing …
Effects of bound versus soluble pentosan polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc regeneration
JE Frith, DJ Menzies, AR Cameron, P Ghosh… - Biomaterials, 2014 - Elsevier
Previous reports in the literature investigating chondrogenesis in mesenchymal progenitor
cell (MPC) cultures have confirmed the chondro-inductive potential of pentosan …
cell (MPC) cultures have confirmed the chondro-inductive potential of pentosan …
Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
D Roufa, A Harel, RCA Frederickson… - US Patent …, 2002 - Google Patents
The present invention relates to the discovery that biocom patible anionic polymers can
effectively inhibit fibrosis, Scar formation, and Surgical adhesions. The invention is predi …
effectively inhibit fibrosis, Scar formation, and Surgical adhesions. The invention is predi …
Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
D Roufa, A Harel, RCA Frederickson… - US Patent …, 2004 - Google Patents
The present invention relates to the discovery that biocom patible anionic polymers can
effectively inhibit fibrosis, Scar formation, and Surgical adhesions. The invention is predi …
effectively inhibit fibrosis, Scar formation, and Surgical adhesions. The invention is predi …