Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats
JK Shaw, I Pamela Alonso, SI Lewandowski… - …, 2021 - nature.com
A major theme of addiction research has focused on the neural substrates of individual
differences in the risk for addiction; however, little is known about how vulnerable …
differences in the risk for addiction; however, little is known about how vulnerable …
[PDF][PDF] Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice
EA Budygin, CE John, Y Mateo… - The Journal of …, 2002 - Soc Neuroscience
Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …
Low or high cocaine responding rats differ in striatal extracellular dopamine levels and dopamine transporter number
AM Nelson, GA Larson, NR Zahniser - Journal of Pharmacology and …, 2009 - ASPET
Both humans and animals exhibit marked individual differences in cocaine responsiveness.
By using the median split of cocaine-induced locomotor activity, we have classified outbred …
By using the median split of cocaine-induced locomotor activity, we have classified outbred …
Chemogenetic manipulation of dopamine neurons dictates cocaine potency at distal dopamine transporters
The reinforcing efficacy of cocaine is largely determined by its capacity to inhibit the
dopamine transporter (DAT), and emerging evidence suggests that differences in cocaine …
dopamine transporter (DAT), and emerging evidence suggests that differences in cocaine …
Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus …
Y Mateo, EA Budygin, CE John, ML Banks… - Journal of neuroscience …, 2004 - Elsevier
Cocaine elevates dopamine (DA) in the nucleus accumbens (NAc) by blocking the uptake of
DA through the DA transporter (DAT). It is commonly believed that the reinforcing properties …
DA through the DA transporter (DAT). It is commonly believed that the reinforcing properties …
Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter
MM McGinnis, CA Siciliano… - Journal of …, 2016 - Wiley Online Library
Cocaine is a commonly abused central nervous system stimulant that enhances dopamine
(DA) neurotransmission through its ability to block dopamine transporters (DAT s). Recent …
(DA) neurotransmission through its ability to block dopamine transporters (DAT s). Recent …
Low and high cocaine locomotor responding male Sprague–Dawley rats differ in rapid cocaine-induced regulation of striatal dopamine transporter function
BH Mandt, NR Zahniser - Neuropharmacology, 2010 - Elsevier
Adult outbred Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively). Importantly, LCRs and HCRs are distinguished …
responders (LCRs or HCRs, respectively). Importantly, LCRs and HCRs are distinguished …
Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic …
SJ Kohut, T Hiranita, SK Hong, AL Ebbs, V Tronci… - Biological …, 2014 - Elsevier
Background Subjective effects of cocaine are mediated primarily by dopamine (DA)
transporter (DAT) blockade. The present study assessed the hypothesis that different DAT …
transporter (DAT) blockade. The present study assessed the hypothesis that different DAT …
Cocaine potency at the dopamine transporter tracks discrete motivational states during cocaine self-administration
CA Siciliano, SR Jones - Neuropsychopharmacology, 2017 - nature.com
Although the dopamine transporter (DAT) is the primary site of action for cocaine, and the
dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic …
dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic …
Cocaine self‐administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine
Dopaminergic projections from the ventral midbrain to the nucleus accumbens (NA c) have
long been implicated in encoding associations between reward availability and …
long been implicated in encoding associations between reward availability and …