Background: The ongoing COVID-19 pandemic has created an alarming situation due to
extensive loss of human lives and economy, posing enormous threat to global health …

COVID-19 caused by SARS-CoV-2 in late 2019 is still threatening global human health.
Although some vaccines and drugs are available in the market, controlling the spread of the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …

Abstract Coronavirus disease 2019 (COVID-19) has been a pandemic disease of which the
termination is not yet predictable. Currently, researches to develop vaccines and treatments …

3CLpro is an attractive target for the treatment of COVID-19. Using the scaffold hopping
strategy, we identified a potent inhibitor of 3CLpro (3a) that contains a thiocyanate moiety as …

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and
Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these …

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has emphasized the urgency to develop effective …

Although no longer a public health emergency of international concern, COVID-19 remains
a persistent and critical health concern. The development of effective antiviral drugs could …

The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

The genus Betacoronavirus includes severe acute respiratory syndrome coronavirus (SARS-
CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Historically, these …