Impact of inflammatory cytokine and adipokine gene variations in the development of HIV‐associated lipodystrophy

G Namdev, R Choudhari, Shyamveer… - The Journal of Gene …, 2023 - Wiley Online Library
Cytokines affect lipid and glucose metabolism and also alter the body's habitus. They play a
role in the development of lipodystrophy syndrome. Adipocytes secrete the pro‐inflammatory …

Adipogenic gene variants in patients with HIV-associated lipodystrophy

SP Pushpakom, A Owen, H Castro… - Pharmacogenetics …, 2011 - journals.lww.com
Objectives Although highly active antiretroviral therapy (HAART) has been hugely beneficial
in the treatment of HIV, HIV lipodystrophy (HIVLD) associated with HAART isaserious …

Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic …

V Jan, P Cervera, M Maachi, M Baudrimont… - Antiviral …, 2004 - journals.sagepub.com
Objective To achieve a better understand of the pathophysiology of HIV-related lipoatrophy,
we compared the mRNA expression of adipocytokines in fat samples from patients and …

Genetic polymorphisms differently influencing the emergence of atrophy and fat accumulation in HIV-related lipodystrophy

BZ Poma, A Riva, M Nasi, P Cicconi, V Broggini… - Aids, 2008 - journals.lww.com
Objective and design: The present study aims at evaluating the influence of genetic
polymorphisms on antiretroviral therapy (ART)-associated lipodystrophy. We included in the …

Correlation of leptin, adiponectin, and resistin levels in different types of lipodystrophy in HIV/AIDS patients

D Srdic, AM Khawla, I Soldatovic, J Nikolic… - … syndrome and related …, 2017 - liebertpub.com
Background: Leptin, adiponectin, and resistin may play an important role in the development
of lipodystrophy (LD) in HIV/AIDS patients. The aim of this study was to correlate levels of …

Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy

S Veloso, X Escoté, V Ceperuelo-Mallafré… - Cytokine, 2012 - Elsevier
Leptin, adiponectin and IL18 are adipokines related with obesity, insulin resistance and
dyslipidemia in the general population. Treated HIV-1-infected patients with lipodystrophy …

[HTML][HTML] Genetic and cytometric analyses of subcutaneous adipose tissue in patients with hemophilia and HIV-associated lipodystrophy

T Mashiko, K Tsukada, H Takada, SH Wu… - AIDS Research and …, 2022 - Springer
Background The authors recently performed plastic surgeries for a small number of patients
with hemophilia, HIV infection, and morphologic evidence of lipodystrophy. Because the …

Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy

M Kratz, JQ Purnell, PA Breen… - The Journal of …, 2008 - academic.oup.com
Context: The expression of adipogenic genes in sc adipose tissue has been reported to be
lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is …

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV‐associated lipodystrophy

Shyamveer, AA Khan, HO Singh - The Journal of Gene …, 2023 - Wiley Online Library
Adipocytes play a crucial role in the metabolism of lipids and sugars. Their response varies
depending on the circumstances or other factors influenced by physiological and metabolic …

Polymorphisms in adiponectin receptor genes are associated with lipodystrophy‐related phenotypes in HIV‐infected patients receiving antiretroviral therapy

JK Castilhos, E Sprinz, RK Lazzaretti… - HIV …, 2015 - Wiley Online Library
Objectives Adiponectin is a circulating peptide secreted by mature adipocytes that may act
as a regulator of glucose and lipid metabolism. This study aimed to investigate the …