Background Methadone is commonly administered for chronic pain relief and treatment of
opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have …

Evidence suggests a link between opioid use and kidney disease. This review summarizes
the known renal manifestations of opioid use including its role in acute and chronic kidney …

Background: Opioids are the mainstay of pain control for patients with chronic pain. Often,
opioids with reported active metabolites, such as morphine and hydromorphone, are thought …

Methadone-associated overdose deaths have dramatically increased. In order to inform an
evidence-based clinical practice guideline to improve safety of methadone prescribing, the …

Abstract Background The United States is faced with an unprecedented epidemic of drug
abuse. Every year thousands of Americans visit the emergency departments all over the …

Discussion Methadone treatment is the most common pharmacological intervention for
opioid dependence [1]. More than 110,000 patients receive methadone treatment in United …

Drug abuse has become a major social problem of the modern world and majority of these
abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal …

Aim The effects of methamphetamine intoxication on the kidney are not well reported. We
aimed to investigate acute kidney injury (AKI) associated with methamphetamine …

In patients suffering from moderate-to-severe chronic kidney disease (CKD) or end-stage
renal disease (ESRD), subjected to hemodialysis (HD), pain is very common, but often …

creatine kinase level was 82.8 pkat/l. blood urea 3.9 mmol/l, creatinine 92 pmol/1. Over the
subsequent days creatine kinase returned to the normal level. A chest roentgenogram on …