[HTML][HTML] An emerging role of pendrin in health and disease
Y Kumai, D Eladari - Physiological Reports, 2015 - ncbi.nlm.nih.gov
The pendrin gene (SLC26A4) was initially identified through the positional cloning in
patients with Pendred syndrome, a heritable recessive genetic disorder (MIM# 274600) …
patients with Pendred syndrome, a heritable recessive genetic disorder (MIM# 274600) …
[HTML][HTML] Reduction of cellular expression levels is a common feature of functionally affected pendrin (SLC26A4) protein variants
VCS de Moraes, E Bernardinelli, N Zocal… - Molecular …, 2016 - Springer
Sequence alterations in the pendrin gene (SLC26A4) leading to functionally affected protein
variants are frequently involved in the pathogenesis of syndromic and nonsyndromic …
variants are frequently involved in the pathogenesis of syndromic and nonsyndromic …
Molecular and functional characterization of human pendrin and its allelic variants
Abstract Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I-, Cl-,
HCO3-, OH-, SCN-and formate. In the thyroid, pendrin is expressed at the apical membrane …
HCO3-, OH-, SCN-and formate. In the thyroid, pendrin is expressed at the apical membrane …
Identification of allelic variants of pendrin (SLC26A4) with loss and gain of function
S Dossena, A Bizhanova, C Nofziger… - Cellular physiology and …, 2011 - karger.com
Background: Pendrin is a multifunctional anion transporter that exchanges chloride and
iodide in the thyroid, as well as chloride and bicarbonate in the inner ear, kidney and …
iodide in the thyroid, as well as chloride and bicarbonate in the inner ear, kidney and …
Pendrin: linking acid base to blood pressure
F Brazier, N Cornière, N Picard, R Chambrey… - … -European Journal of …, 2024 - Springer
Abstract Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which
is mutated in human patients affected by Pendred syndrome, an autosomal recessive …
is mutated in human patients affected by Pendred syndrome, an autosomal recessive …
[HTML][HTML] Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger
Q Liu, X Zhang, H Huang, Y Chen, F Wang… - Nature …, 2023 - nature.com
Abstract Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of
selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder …
selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder …
[HTML][HTML] Mechanism of anion exchange and small-molecule inhibition of pendrin
Abstract Pendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO3−)
exchange for chloride (Cl−) and is crucial for maintaining pH and salt homeostasis in the …
exchange for chloride (Cl−) and is crucial for maintaining pH and salt homeostasis in the …
The ESF Meeting on „The Proteomics, Epigenetics and Pharmacogenetics of Pendrin “
Abstract Human pendrin (SCL26A4, PDS) is a 780 amino acid integral membrane protein
with transport function. It acts as an electroneutral, sodium-independent anion exchanger for …
with transport function. It acts as an electroneutral, sodium-independent anion exchanger for …
Regulation of pendrin by pH: dependence on glycosylation
A Azroyan, K Laghmani, G Crambert… - Biochemical …, 2011 - portlandpress.com
Mutations in the anion exchanger pendrin are responsible for Pendred syndrome, an
autosomal recessive disease characterized by deafness and goitre. Pendrin is highly …
autosomal recessive disease characterized by deafness and goitre. Pendrin is highly …