Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage

MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2016 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …

Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage

MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in …

E Aref-Eshghi, Y Zhang, M Liu, PE Harper… - BMC musculoskeletal …, 2015 - Springer
Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …

[PDF][PDF] Characterization of the cartilage DNA methylome in knee and hip osteoarthritis

MD Rushton, LN Reynard, MJ Barter… - Arthritis & …, 2014 - Wiley Online Library
Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

W Den Hollander, YFM Ramos, SD Bos… - Annals of the …, 2014 - ard.bmj.com
Objectives To elucidate the functional epigenomic landscape of articular cartilage in
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …

Use of integrative epigenetic and mRNA expression analyses to identify significantly changed genes and functional pathways in osteoarthritic cartilage

A He, Y Ning, Y Wen, Y Cai, K Xu, J Han… - Bone & joint …, 2018 - boneandjoint.org.uk
Aim Osteoarthritis (OA) is caused by complex interactions between genetic and
environmental factors. Epigenetic mechanisms control the expression of genes and are …

Identification of DNA methylation changes associated with disease progression in subchondral bone with site-matched cartilage in knee osteoarthritis

Y Zhang, N Fukui, M Yahata, Y Katsuragawa… - Scientific Reports, 2016 - nature.com
Subchondral bone plays a key role in the development of osteoarthritis, however,
epigenetics of subchondral bone has not been extensively studied. In this study, we …

Identification of differentially methylated regions in new genes associated with knee osteoarthritis

CA Bonin, EA Lewallen, S Baheti, EW Bradley… - Gene, 2016 - Elsevier
Epigenetic changes in articular chondrocytes are associated with osteoarthritis (OA) disease
progression. Numerous studies have identified differentially methylated cytosines in OA …

Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage

O Alvarez‐Garcia, KM Fisch… - Arthritis & …, 2016 - Wiley Online Library
Objective To analyze the methylome of normal and osteoarthritic (OA) knee articular
cartilage and to determine the role of DNA methylation in the regulation of gene expression …

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

J Fernández-Tajes, A Soto-Hermida… - Annals of the …, 2014 - ard.bmj.com
Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …