Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2016 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …
methylation patterns in subchondral bone underlying eroded and intact cartilage from …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in …
E Aref-Eshghi, Y Zhang, M Liu, PE Harper… - BMC musculoskeletal …, 2015 - Springer
Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
[PDF][PDF] Characterization of the cartilage DNA methylome in knee and hip osteoarthritis
MD Rushton, LN Reynard, MJ Barter… - Arthritis & …, 2014 - Wiley Online Library
Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …
Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches
Objectives To elucidate the functional epigenomic landscape of articular cartilage in
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …
Use of integrative epigenetic and mRNA expression analyses to identify significantly changed genes and functional pathways in osteoarthritic cartilage
A He, Y Ning, Y Wen, Y Cai, K Xu, J Han… - Bone & joint …, 2018 - boneandjoint.org.uk
Aim Osteoarthritis (OA) is caused by complex interactions between genetic and
environmental factors. Epigenetic mechanisms control the expression of genes and are …
environmental factors. Epigenetic mechanisms control the expression of genes and are …
Identification of DNA methylation changes associated with disease progression in subchondral bone with site-matched cartilage in knee osteoarthritis
Y Zhang, N Fukui, M Yahata, Y Katsuragawa… - Scientific Reports, 2016 - nature.com
Subchondral bone plays a key role in the development of osteoarthritis, however,
epigenetics of subchondral bone has not been extensively studied. In this study, we …
epigenetics of subchondral bone has not been extensively studied. In this study, we …
Identification of differentially methylated regions in new genes associated with knee osteoarthritis
Epigenetic changes in articular chondrocytes are associated with osteoarthritis (OA) disease
progression. Numerous studies have identified differentially methylated cytosines in OA …
progression. Numerous studies have identified differentially methylated cytosines in OA …
Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage
O Alvarez‐Garcia, KM Fisch… - Arthritis & …, 2016 - Wiley Online Library
Objective To analyze the methylome of normal and osteoarthritic (OA) knee articular
cartilage and to determine the role of DNA methylation in the regulation of gene expression …
cartilage and to determine the role of DNA methylation in the regulation of gene expression …
Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients
J Fernández-Tajes, A Soto-Hermida… - Annals of the …, 2014 - ard.bmj.com
Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …