[HTML][HTML] DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism

J Shen, C Wang, D Li, T Xu, J Myers, JM Ashton… - JCI insight, 2017 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common form of arthritis worldwide. It is a complex disease
affecting the whole joint but is generally characterized by progressive degradation of …

Specific increase of methylation age in osteoarthritis cartilage

L Vidal, Y Lopez-Golan, I Rego-Perez… - Osteoarthritis and …, 2016 - oarsijournal.com
Purpose: The major risk factor for osteoarthritis (OA) is old age. However, the relationship
between aging and OA is incompletely understood. Among the joint changes associated …

[HTML][HTML] The methylation pattern for knee and hip osteoarthritis

Z Wu, L Shou, J Wang, T Huang, X Xu - Frontiers in Cell and …, 2020 - frontiersin.org
Osteoarthritis is one of the most prevalent chronic joint diseases for middle-aged and elderly
people. But in recent years, the number of young people suffering from the disease …

Differential association of mitochondrial DNA haplogroups J and H with the methylation status of articular cartilage: potential role in apoptosis and metabolic and …

E Cortés‐Pereira, J Fernández‐Tajes… - Arthritis & …, 2019 - Wiley Online Library
Objective To analyze the influence of mitochondrial genome variation on the DNA
methylome of articular cartilage. Methods DNA methylation profiling was performed using …

[HTML][HTML] Osteoarthritis year in review 2016: genetics, genomics and epigenetics

JBJ Van Meurs - Osteoarthritis and cartilage, 2017 - Elsevier
The purpose of this narrative review is to provide an overview of last year's publications in
the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes …

Genome‐wide expression and methylation profiles reveal candidate genes and biological processes underlying synovial inflammatory tissue of patients with …

J Yang, N Wang - International journal of rheumatic diseases, 2015 - Wiley Online Library
Aim The aim of the study was to identify osteoarthritis (OA)‐related biological markers and
processes. Methods The gene expression profile GSE 46750 including 12 normal and 12 …

Evolution and advancements in genomics and epigenomics in OA research: How far we have come

YFM Ramos, SJ Rice, SA Ali, C Pastrello… - Osteoarthritis and …, 2024 - Elsevier
Objective Osteoarthritis (OA) is the most prevalent musculoskeletal disease affecting
articulating joint tissues, resulting in local and systemic changes that contribute to increased …

[HTML][HTML] Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

MJ Barter, C Bui, DA Young - Osteoarthritis and cartilage, 2012 - Elsevier
Osteoarthritis (OA) is a complex multifactorial disease with a strong genetic component.
Several studies have suggested or identified epigenetic events that may play a role in OA …

[HTML][HTML] Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

J Hao, Y Liu, J Xu, W Wang, Y Wen, A He… - Arthritis Research & …, 2017 - Springer
Background Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease.
Little is known about the potential role of DNA methylation in the pathogenesis of AS. This …

Epigenomic profiling of the infrapatellar fat pad in osteoarthritis

P Kreitmaier, YC Park, D Swift, A Gilly… - Human Molecular …, 2024 - academic.oup.com
Osteoarthritis is a prevalent, complex disease of the joints, and affects multiple intra-articular
tissues. Here, we have examined genome-wide DNA methylation profiles of primary …