Objective Human articular chondrocytes do not express COL10A1 and do not undergo
hypertrophy except in close vicinity to subchondral bone. In contrast, chondrocytes produced …

Objective Over 100 DNA variants have been associated with osteoarthritis (OA), including
rs1046934, located within a linkage disequilibrium block encompassing part of COLGALT2 …

DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …

Objective The lack of accurate biomarkers to predict knee osteoarthritis (OA) progression is
a key unmet need in OA clinical research. The objective of this study was to develop …

Introduction: Changes occurring in the chondrocyte gene that control articular cartilage are
important for the onset and progression of osteoarthritis (OA). However, actual development …

Epigenetic regulation is a vital driver of the aetiology of human disease, with research
breakthroughs now occurring on a regular basis. Several studies investigating CpG …

Rheumatoid arthritis (RA) is a complex chronic systematic disease with progressive
destruction of the joints by invasive synoviocytes. To characterize the key regulators …

Osteoarthritis (OA) is a common complex disease of high public health burden. OA is
characterized by the degeneration of affected joints leading to pain and reduced mobility …

Objective To compare DNA methylation in subjects positive vs negative for anti-citrullinated
protein antibodies (ACPA), a key serological marker of rheumatoid arthritis (RA) risk …

Osteoarthritis (OA) is the most prevalent chronic age-related arthritic disease that mainly
affects the diarthrodial joints. Nevertheless, there is no treatment currently available that can …