Background Investigation of cartilage and chondrocytes has revealed that the osteoarthritis
risk marked by the independent DNA variants rs11583641 and rs1046934 mediate their …

DNA methylation has emerged as a crucial regulator of chondrocyte dedifferentiation, which
severely compromises the outcome of autologous chondrocyte implantation (ACI) treatment …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Osteoarthritis (OA) is one of the most prevalent forms of joint disorder, associated with a
tremendous socioeconomic burden worldwide. Various non-genetic and lifestyle-related …

Background Rheumatoid arthritis is a common autoimmune disorder influenced by both
genetic and environmental factors. Epigenome-wide association studies can identify …

Stratifying patients on the basis of molecular signatures could facilitate development of
therapeutics that target pathways specific to a particular disease or tissue location. Previous …

Multiple reports now describe changes to the DNA methylome in rheumatoid arthritis and in
many cases have analyzed methylation in mixed cell populations from whole blood …

Background Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease
of the joints that has been associated with variation in the peripheral blood methylome. In …

Objective Human synovium–derived mesenchymal stem cells (MSCs) can efficiently
differentiate into mature chondrocytes. It has been suggested that DNA methylation is one …

Osteoarthritis (OA) is a complicated disease with both hereditary and environmental causes.
Despite an increase in reports of possible OA risk loci, it has become clear that genetics is …