Abstract Development of mammalian B-lineage cells is characterized by progression
through a series of checkpoints defined primarily by rearrangement and expression of …

Transcription factors influence B cell differentiation by regulating the expression of
numerous lineage-specific genes. Recent studies have identified factors that regulate …

B cells are a central component of the humoral arm of the immune system and are essential
in protecting against infection and disease. They mediate their effector functions through the …

During the last several decades, significant progress has been made in understanding the
roles of B cells in immunity and autoimmunity. B-cell development, occurring in the bone …

Many fundamental concepts about immune system development have changed
substantially in the past few years, and rapid advances with animal models are presenting …

We describe here three CD19− B cell precursor populations in mouse bone marrow
identified using 12-color flow cytometry. Cell transfer experiments indicate lineage potentials …

B lymphocytes, the cellular source of antibody, are critical components of the immune
response. They develop from multipotential stem cells, progressively acquiring the traits that …

Transitional B cells mark the crucial link between bone-marrow (BM) immature and
peripheral mature B cells. Examination reveals unexpected heterogeneity, consisting of …

Studies over the last decade uncovered overlapping niches for hematopoietic stem cells
(HSC s), multipotent progenitor cells, common lymphoid progenitors, and early B cell …

Highlights•Multiple intrinsic and extrinsic inputs control B cell terminal differentiation.•
Differentiation is associated with loss of CpG methylation at promoters/enhancers.•Ezh2 …