Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

For decades, we have presumed the death of hair cells and spiral ganglion neurons are the
main cause of hearing loss and difficulties understanding speech in noise, but new findings …

Cochlear synaptopathy can result from various insults, including acoustic trauma, aging,
ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in …

In rodents, exposure to high-level noise can destroy synapses between inner hair cells and
auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such …

Although there is strong histological evidence for age-related synaptopathy in humans,
evidence for the existence of noise-induced cochlear synaptopathy in humans is …

Prior work has provided extensive documentation of threshold sensitivity and sensory hair
cell losses after noise exposure. It is now clear, however, that cochlear synaptic loss …

Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies.
In these animal models, the disorder is characterized by a reduction in amplitude of wave I of …

Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …

Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between
inner hair cells (IHCs) and auditory-nerve fibers (ANFs), first reported in CBA/CaJ mice …

Understanding the biology of the previously underappreciated sensitivity of cochlear
synapses to noise insult, and its clinical consequences, is becoming a mission for a growing …