Pathogenesis of heparin-induced thrombocytopenia

GM Arepally, DB Cines - Translational Research, 2020 - Elsevier
There are currently no effective substitutes for high intensity therapy with unfractionated
heparin (UFH) for cardiovascular procedures based on its rapid onset of action, ease of …

Recent advances in the diagnosis and treatment of heparin-induced thrombocytopenia

T Bakchoul, A Greinacher - Therapeutic advances in …, 2012 - journals.sagepub.com
Heparin-induced thrombocytopenia (HIT) is a drug-mediated, prothrombotic disorder caused
by immunization against platelet factor 4 (PF4) after complex formation with heparin or other …

Heparin-induced thrombocytopenia

GM Arepally, TL Ortel - Annual review of medicine, 2010 - annualreviews.org
Heparin-induced thrombocytopenia (HIT) is an immune-mediated hypercoagulable disorder
caused by antibodies to platelet factor 4 (PF4) and heparin. HIT develops in temporal …

Heparin-induced thrombocytopenia

GM Lee, GM Arepally - Hematology 2013, the American Society …, 2013 - ashpublications.org
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies
that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered …

Heparin-induced thrombocytopenia: a contemporary clinical approach to diagnosis and management

E Shantsila, GYH Lip, BH Chong - Chest, 2009 - Elsevier
Thrombocytopenia following heparin administration can be associated with an immune
reaction, now referred to as heparin-induced thrombocytopenia. HIT is essentially a …

Heparin-induced thrombocytopenia

GM Arepally - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy
caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic …

Clinical and laboratory diagnosis of heparin-induced thrombocytopenia: an integrated approach

A Cuker - Seminars in thrombosis and hemostasis, 2014 - thieme-connect.com
Heparin-induced thrombocytopenia (HIT) is a clinicopathologic disorder that predisposes to
thrombosis. Diagnosis rests on a compatible clinical picture and laboratory evidence of …

Heparin-induced thrombocytopenia

F Fabris, G Luzzatto, PM Stefani, B Girolami… - …, 2000 - haematologica.org
BACKGROUND AND OBJECTIVE: There are two types of heparin-induced
thrombocytopenia (HIT). HIT I is characterized by a transitory, slight and asymptomatic …

How I diagnose and manage HIT

TE Warkentin - Hematology 2010, the American Society of …, 2011 - ashpublications.org
Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-
activating IgG antibodies that recognize platelet factor 4 (PF4)/polyanion complexes. Platelet …

Heparin-induced thrombocytopenia: a clinicopathologic syndrome

TE Warkentin - Thrombosis and haemostasis, 1999 - thieme-connect.com
The American vascular surgeons, Weismann and Tobin in 1958 1 and Roberts and
colleagues in 1964, 2 were the first to describe unusual thrombi affecting the lower limb …