One of the key challenges in engineering three-dimensional tissue constructs is the
development of a mature microvascular network capable of supplying sufficient oxygen and …

Long-term viability of thick three-dimensional engineered tissue constructs is a major
challenge. Addressing it requires development of vessel-like network that will allow the …

Long-term function of three-dimensional (3D) tissue constructs depends on adequate
vascularization after implantation. Accordingly, research in tissue engineering has focused …

Despite the steady increase in the number of studies focusing on the development of tissue
engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack …

Tissue engineering is touted as the new medical alchemy. Using a combination of cells,
especially stem cells, and scaffold matrices, it offers a novel approach that mimics …

This review focuses on vascularization and strategies involved in its evaluation and
modulation. Clinical issues associated with engineered tissues of an atomically relevant size …

Engineered tissues need a vascular network to supply cells with nutrients and oxygen after
implantation. A network that can connect to the vasculature of the patient after implantation …

Tissue engineering is an interdisciplinary field of biomedical research that aims for the
restoration of tissue defects or even the replacement of complete organs (Griffith and …

Cardiovascular disease is a primary cause of mortality worldwide, and patients often require
bypass surgery that utilizes autologous vessels as conduits. However, the limited availability …

Vascularisation is often deemed the holy grail of tissue engineering because it is one of the
key preconditions that determine the in vivo viability of tissue constructs. Given that a well …