Stable isotope chemical labeling liquid chromatography-mass spectrometry (LC-MS) is a
powerful strategy for comprehensive metabolomics profiling, which can improve metabolites …

Metabolite isomers play diverse and crucial roles in various metabolic processes. However,
in untargeted metabolomics analysis, it remains a great challenge to distinguish between …

Tandem mass spectrometry (MS/MS)-based relative quantification by isobaric labeling is a
useful technique to compare different metabolic expression levels in biological systems. For …

Polar phosphorylated metabolites are involved in a variety of biological processes and play
vital roles in energetic metabolism, cofactor regeneration, and nucleic acid synthesis …

Here, we have documented a new protocol to determine d/l-amino acids by derivatizing
amino acids via a chiral phosphinate.(RP)-l-Menthyl phenylphosphinate was able to bond …

Metabolomic profiling involves relative quantification of metabolites in comparative samples
and identification of the significant metabolites that differentiate different groups (eg …

One of the challenges associated with metabolome profiling in complex biological samples
is to generate quantitative information on the metabolites of interest. In this work, a targeted …

Amino acid analysis with high performance liquid chromatography with electrospray
ionization mass spectrometry (LC–ESI-MS) is an emerging method. For more sensitive …

A novel method based on the strategy of N-phosphorylation labeling is described for
quantification of twenty natural amino acids in human serum by reversed-phase liquid …

N-phosphorylation labeling was utilized to analyze the low molecular weight compounds by
using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI …