A molecular census of arcuate hypothalamus and median eminence cell types

JN Campbell, EZ Macosko, H Fenselau, TH Pers… - Nature …, 2017 - nature.com
The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …

Ontogenetic rules for the molecular diversification of hypothalamic neurons

M Benevento, T Hökfelt, T Harkany - Nature reviews neuroscience, 2022 - nature.com
The hypothalamus is an evolutionarily conserved endocrine interface that, among other
roles, links central homeostatic control to adaptive bodily responses by releasing hormones …

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

JR Moffitt, D Bambah-Mukku, SW Eichhorn, E Vaughn… - Science, 2018 - science.org
INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

[PDF][PDF] EASI-FISH for thick tissue defines lateral hypothalamus spatio-molecular organization

Y Wang, M Eddison, G Fleishman, M Weigert, S Xu… - Cell, 2021 - cell.com
Determining the spatial organization and morphological characteristics of molecularly
defined cell types is a major bottleneck for characterizing the architecture underpinning …

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

FE Henry, K Sugino, A Tozer, T Branco, SM Sternson - Elife, 2015 - elifesciences.org
Molecular and cellular processes in neurons are critical for sensing and responding to
energy deficit states, such as during weight-loss. Agouti related protein (AGRP)-expressing …

Rax is a selector gene for mediobasal hypothalamic cell types

F Lu, D Kar, N Gruenig, ZW Zhang… - Journal of …, 2013 - Soc Neuroscience
The brain plays a central role in controlling energy, glucose, and lipid homeostasis, with
specialized neurons within nuclei of the mediobasal hypothalamus, namely the arcuate …

Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

LE Mickelsen, M Bolisetty, BR Chimileski, A Fujita… - Nature …, 2019 - nature.com
The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors,
including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of …

[HTML][HTML] Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators

C Huisman, H Cho, O Brock, SJ Lim, SM Youn… - Nature …, 2019 - nature.com
Despite the crucial physiological processes governed by neurons in the hypothalamic
arcuate nucleus (ARC), such as growth, reproduction and energy homeostasis, the …

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

RA Romanov, A Zeisel, J Bakker, F Girach… - Nature …, 2017 - nature.com
The hypothalamus contains the highest diversity of neurons in the brain. Many of these
neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner …

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

DA Lee, JL Bedont, T Pak, H Wang, J Song… - Nature …, 2012 - nature.com
Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the
function of these newborn neurons are unknown. Using genetic fate mapping, we found that …