The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …

The hypothalamus is an evolutionarily conserved endocrine interface that, among other
roles, links central homeostatic control to adaptive bodily responses by releasing hormones …

INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

Determining the spatial organization and morphological characteristics of molecularly
defined cell types is a major bottleneck for characterizing the architecture underpinning …

Molecular and cellular processes in neurons are critical for sensing and responding to
energy deficit states, such as during weight-loss. Agouti related protein (AGRP)-expressing …

The brain plays a central role in controlling energy, glucose, and lipid homeostasis, with
specialized neurons within nuclei of the mediobasal hypothalamus, namely the arcuate …

The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors,
including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of …

Despite the crucial physiological processes governed by neurons in the hypothalamic
arcuate nucleus (ARC), such as growth, reproduction and energy homeostasis, the …

The hypothalamus contains the highest diversity of neurons in the brain. Many of these
neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner …

Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the
function of these newborn neurons are unknown. Using genetic fate mapping, we found that …