Skeletal muscles are highly plastic tissues capable dramatic remodeling in response to use,
disuse, disease, and other factors. Growing evidence suggests that adipose tissues exert …

Objective To investigate whether differences in muscle fiber types affect early-stage fat
accumulation, under high fat diet challenge in mice. Methods Twelve healthy male C57BL/6 …

In this study, we investigated the effects of a short‐term and long‐term high‐fat diet (HFD) on
morphological and functional features of fast‐twitch skeletal muscle. Male C57 BL/6J mice …

Obesity and aging reduce skeletal muscle contractile function. However, it remains unclear
whether obesity additively promotes muscle contractile dysfunction in the setting of aging. In …

Ageing and obesity independently have been shown to significantly impair isolated muscle
contractile properties, though their synergistic effects are poorly understood. We uniquely …

The incidence of obesity and obesity‐related conditions, such as metabolic syndrome and
insulin resistance, is on the increase. The effect of obesity on skeletal muscle function …

Background: Knowledge of the morphological and biochemical alterations occurring in
skeletal muscles of obese animals is relatively limited, particularly with respect to non-limb …

Loss of skeletal muscle mass and function occurs with increasing age. Calorie restriction
(CR) increases the lifespan of C57Bl/6 mice, but not in the shorter-lived DBA/2 strain. There …

The loss of skeletal muscle mass is observed in many pathophysiological conditions,
including aging and obesity. The loss of muscle mass and function with aging is defined as …

Background: Ectopic fat accumulation in skeletal muscle results in dysfunction and atrophy,
but the underlying molecular mechanisms remain unclear. Objective: The aim of this study …