Purpose Recent evidence has demonstrated an obesity-induced, skeletal muscle-specific
reduction in contractile performance. The extent and magnitude of these changes in relation …

OBJECTIVE Although advanced age is a risk factor for type 2 diabetes, a clear
understanding of the changes that occur during middle age that contribute to the …

Background Diet-induced obesity is a rising health concern which can lead to the
development of glucose intolerance and muscle insulin resistance and, ultimately, type II …

The present study aimed to simultaneously examine the age-related, muscle-specific, sex-
specific, and contractile mode-specific changes in isolated mouse skeletal muscle function …

Skeletal muscle extracellular matrix (ECM) remodelling has been proposed as a feature of
the pathogenic milieu associated with obesity and metabolic dysfunction. Whether muscle …

Previously, we monitored the expression level of the pro-apoptotic proteins caspase-3 and
cleaved poly-ADP-ribose polymerase in the skeletal muscle of high-fat diet-induced obese …

A high-saturated-fat diet (HFD) induces obesity and insulin resistance (IR). IR has been
linked to alterations and increased saturation in the phospholipid composition of skeletal …

High-fat diets (HFDs) have been shown to interfere with skeletal muscle energy metabolism
and cause peripheral insulin resistance. However, understanding of HFD impact on skeletal …

Background Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin
expression and leads to severe ambulatory and cardiac function decline. However, the …

The absence of functional dystrophin protein in patients with Duchenne muscular dystrophy
(DMD) and dystrophic mdx mice leads to fragile myofibre membranes and cycles of myofibre …