The relationship between serum uric acid (SUA) and hypertension has been a subject of
increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several …

Uric acid is the final product of purine metabolism, and its increased serum levels have been
directly involved in the pathogenesis and natural history of hypertension. The relationship …

The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …

Increased levels of uric acid are associated with cardiovascular disease and the metabolic
syndrome. They may predict clinical outcomes and also the onset of hypertension, though it …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

The association between serum uric acid levels and high blood pressure in humans is well
established. For example, a cross-sectional study determined that each 1mg/dL increase in …

Uric acid levels are higher in humans than in other mammals. Best known as an
extracellular antioxidant, uric acid also increases salt sensitivity, fat storage, and …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

Uric acid was first associated with primary hypertension in 1874, yet its role in this condition
remains unclear. Historically, uric acid was thought to be a secondary response to …

Current evidence supports the role of uric acid as marker and mediator of risk for both
hypertension and progressive decline in renal function. Data on the impact of xanthine …