Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion

HM Dungan, DK Clifton, RA Steiner - Endocrinology, 2006 - academic.oup.com
The Kiss1 gene encodes a family of peptides called kisspeptins, which bind to the G protein-
coupled receptor GPR54. Kisspeptin (s) and its receptor are expressed in the forebrain, and …

Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis

ML Gottsch, DK Clifton, RA Steiner - Molecular and cellular endocrinology, 2006 - Elsevier
Kisspeptins, which are products of the Kiss1 gene, and their receptor, GPR54, have
emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) …

The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction

SM Popa, DK Clifton, RA Steiner - Annu. Rev. Physiol., 2008 - annualreviews.org
Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …

The role of kisspeptin–GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone

HM Dungan, ML Gottsch, H Zeng… - Journal of …, 2007 - Soc Neuroscience
The Kiss1 gene codes for kisspeptin, which binds to GPR54, a G-protein-coupled receptor.
Kisspeptin and GPR54 are expressed in discrete regions of the forebrain, and they have …

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse

ML Gottsch, MJ Cunningham, JT Smith, SM Popa… - …, 2004 - academic.oup.com
Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor
known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause …

Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion

E Gutiérrez‐Pascual… - Journal of …, 2007 - Wiley Online Library
Recent, compelling evidence indicates that kisspeptins, the products of KiSS‐1 gene, and
their receptor GPR54, represent key elements in the neuroendocrine control of reproduction …

[HTML][HTML] Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling

JT Smith, DK Clifton, RA Steiner - Reproduction, 2006 - rep.bioscientifica.com
The Kiss1 gene codes for a family of peptides that act as endogenous ligands for the G
protein-coupled receptor GPR54. Spontaneous mutations or targeted deletions of GPR54 in …

Kisspeptin signaling in the brain

AE Oakley, DK Clifton, RA Steiner - Endocrine reviews, 2009 - academic.oup.com
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty

UB Kaiser, W Kuohung - Endocrine, 2005 - Springer
The recent identification of loss-of-function mutations in the gene encoding GPR54, the
receptor for the KiSS-1-derived peptides, kisspeptins, has highlighted a previously …

Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines

HJ Novaira, Y Ng, A Wolfe, S Radovick - Molecular and cellular …, 2009 - Elsevier
Kisspeptins, and their G-protein coupled receptor 54 (GPR54), are key components in the
regulation of gonadotropin-releasing hormone (GnRH) secretion in humans and other …