Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential

H Rahimi, R Bell, EM Bouta, RW Wood, L Xing… - Arthritis Research & …, 2016 - Springer
Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node
volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore …

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

EM Bouta, RD Bell, H Rahimi, L Xing… - Nature Reviews …, 2018 - nature.com
Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …

The role of the lymphatic system in inflammatory-erosive arthritis

EM Bouta, J Li, Y Ju, EB Brown, CT Ritchlin… - Seminars in cell & …, 2015 - Elsevier
Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease with enigmatic flares,
which causes swelling, pain, and irreversible connective tissue damage. Recently, it has …

In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice

EM Bouta, RW Wood, EB Brown… - The Journal of …, 2014 - Wiley Online Library
Key points Previously, it was found that the popliteal lymph node (PLN) enlarges during the
pre‐arthritic 'expanding'phase, and then 'collapses' with adjacent knee flare and is …

[PDF][PDF] Validation of 3-dimensional ultrasound versus magnetic resonance imaging quantification of popliteal lymph node volume as a biomarker of erosive …

Y Ju, H Rahimi, J Li, RW Wood, L Xing… - Arthritis and …, 2012 - drive.google.com
Draining lymph node (LN) enlargement has long been recognized as a hallmark of joint
inflammation in rheumatoid arthritis (RA) and can be quantified with magnetic resonance …

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling

A Manzo, M Bombardieri, F Humby… - Immunological …, 2010 - Wiley Online Library
Rheumatoid arthritis is a chronic systemic inflammatory disease primarily affecting the
synovium of diarthrodial joints. Despite the currently unknown etiology, overwhelming …

Relationship between lymph node volume and pain following certolizumab therapy for rheumatoid arthritis flare: a pilot study

H Rahimi, G Dieudonne, V Kheyfits… - Clinical Medicine …, 2016 - journals.sagepub.com
Objectives The mechanisms that trigger flare in rheumatoid arthritis (RA) are unknown. In
murine arthritis models, dysfunctional lymph node (LN) drainage is associated with joint …

Subclinical remodelling of draining lymph node structure in early and established rheumatoid arthritis assessed by power Doppler ultrasonography

A Manzo, R Caporali, B Vitolo, S Alessi… - …, 2011 - academic.oup.com
Objective. To investigate the suitability of power Doppler ultrasonography (PD-US) for the
assessment of lymph node (LN) status in RA, evaluating the existence of structural and …

The draining lymph node in rheumatoid arthritis: current concepts and research perspectives

F Benaglio, B Vitolo, M Scarabelli… - BioMed Research …, 2015 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of unknown
aetiology, leading to progressive damage of bone and cartilage with functional impairment …

[HTML][HTML] Lymphatic vessels: roles and potential therapeutic intervention in rheumatoid arthritis and osteoarthritis

S Zhou, G Zhao, R Chen, Y Li, J Huang, L Kuang… - Theranostics, 2024 - ncbi.nlm.nih.gov
Lymphatic vessel networks are a main part of the vertebrate cardiovascular system, which
participate in various physiological and pathological processes via regulation of fluid …