The inappropriate accumulation and activation of leukocytes is a shared pathological feature
of immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA) and …

While erosion and tissue necrosis are the end‐stage result of inflammatory arthritis, factors
that can predict their initiation and severity are unknown. In an effort to identify these …

Rheumatoid arthritis is a chronic inflammatory disease manifested by episodic flares in
affected joints that are challenging to predict and treat. Longitudinal contrast enhanced-MRI …

Objective B cell depletion therapy ameliorates rheumatoid arthritis by mechanisms that are
incompletely understood. Arthritis flare in tumor necrosis factor (TNF)–transgenic mice is …

Background Emerging research on the mechanisms of disease chronicity in experimental
arthritis has included a new focus on the draining lymph node (LN). Here, we combined …

Rheumatoid arthritis (RA) is a chronic autoimmune disease with episodic flares in affected
joints; the etiology of RA is largely unknown. Recent studies in mice demonstrated that …

Background Osteoarthritis (OA) affects the entire joint, initially with a low degree of
inflammation. Synovitis is correlated with the severity of OA clinical symptoms and cartilage …

Objective To develop an in vivo imaging method to assess lymphatic draining function in the
K/BxN mouse model of inflammatory arthritis. Methods Indocyanine green, a near‐infrared …

Objective The synovial lymphatic system (SLS) removes catabolic factors from the joint.
Vascular endothelial growth factor C (VEGF‐C) and its receptor, VEGFR‐3, are crucial for …

Introduction A pivotal effect of lymphatic vessel (LV) function in joint homeostasis was
identified in the tumor necrosis factor-transgenic (TNF-Tg) mouse model of rheumatoid …