Objective This study was undertaken to investigate the effect of lymphatic inhibition on joint
and draining lymph node (LN) pathology during the course of arthritis progression in mice …

Background Increasing numbers of patients (up to 40%) with rheumatoid arthritis (RA)
achieve remission, yet it remains to be elucidated whether this also normalizes their …

Background Angiogenesis is considered an important factor in the pathogenesis of
Rheumatoid Arthritis (RA) where it has been proposed as a therapeutic target. In other …

Objective To investigate the roles of the synovial lymphatic system in the severity and
progression of joint tissue damage and functional responses of synovial lymphatic …

The first immune-activating changes within joint resident cells that lead to pathogenic
leukocyte recruitment during articular inflammation remain largely unknown. In this study, we …

Background Our previous studies reveal that impaired draining function of the synovial
lymphatic vessel (LV) contributes to the pathogenesis of inflammatory arthritis, but the …

Objective: To investigate the presence and regulation of lymphatic vessels in inflamed joints
of mice with experimental arthritis as well as patients with rheumatoid arthritis (RA) and …

Tertiary lymphoid structures (TLSs) in chronic inflammation, including rheumatoid arthritis
(RA) synovial tissue (ST), often contain high endothelial venules and follicular dendritic cells …

Inflammation of non-barrier immunologically quiescent tissues is associated with a massive
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease targeting the joints.
Current treatment strategies are based on clinical, biological and radiological features, yet …