Type 2 diabetes mellitus (T2DM) affects millions of people and is linked with obesity and
lipid accumulation in peripheral tissues. Increased lipid handling and lipotoxicity in insulin …

Mice, deficient for vascular endothelial growth factor VEGF-A in pancreatic islets, have
reduced insulin gene expression levels and an impaired glucose tolerance. Here, we …

VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-
specific vasculature, and Insulin secretion. However, two key questions remain. First, is …

Aims/hypothesis Vascular endothelial growth factor (VEGF) has been recognised by loss-of-
function experiments as a pleiotropic factor with importance in embryonic pancreas …

In recent years, studies have demonstrated that vascular endothelial growth factor B
(VEGFB) can affect the metabolism of fatty acids and glucose, and it is expected to become a …

The prevalence of type 2 diabetes is rapidly increasing, with severe socioeconomic impacts,.
Excess lipid deposition in peripheral tissues impairs insulin sensitivity and glucose uptake …

Type 2 diabetes (T2D) results from insulin resistance and inadequate insulin secretion.
Insulin resistance initially causes compensatory islet hyperplasia that progresses to islet …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

It is generally accepted that vascularization and oxygenation of pancreatic islets are
essential for the maintenance of an optimal β-cell mass and function and that signaling by …

Obesity comprises great risks for human health, contributing to the development of other
diseases such as metabolic syndrome, type 2 diabetes and cardiovascular disease …