Tumor cells are eliminated by the immune system, including T lymphocytes and natural killer
cells, however, many types of tumor cells acquire the immune tolerance by inhibiting T-cell …

Purpose Lysophosphatidic acid (LPA) is a multifunctional lipid mediator involved in
triggering tumor cell invasion and metastasis, as well as malignant cell growth. LPA is also …

Lysophospholipids have emerged as biologically important chemoattractants capable of
directing lymphocyte development, trafficking, and localization. Lysophosphatidic acid (LPA) …

Mounting evidence suggests that inhibition of protein phosphatase-2A (PP2A), a
serine/threonine phosphatase, could enhance anticancer immunity. However, drugs …

Since the early 20th century, immunologists have investigated mechanisms that protect
vertebrates from damaging immune responses against self-antigens by mature lymphocytes …

Despite the remarkable success and efficacy of immune checkpoint blockade (ICB) therapy
against the PD-1/PD-L1 axis, it induces sustained responses in a sizeable minority of cancer …

A recent study by Yao et al. published in Nature Biomedical Engineering showed the
importance of palmitoylation in regulating PD-L1 protein stability and trafficking. 1 These …

Monophosphoryl lipid A (MPLA) is a toll-like receptor 4 ligand that promotes immune
activation in mice and humans, without undesired inflammation. Immunotherapy by the …

The low response rate of immune checkpoint inhibitors (ICIs) is a challenge. The efficacy of
ICIs is influenced by the tumour microenvironment, which is controlled by the gut microbiota …

Lysophosphatidic acid (LPA) is a ubiquitously present signalling molecule involved in
diverse cellular processes such as cell migration, proliferation and differentiation. LPA acts …