Bone tissue engineering is an exciting approach to directly repair bone defects or engineer
bone tissue for transplantation. Biomaterials play a pivotal role in providing a template and …

With an increasing life expectancy and aging population, orthopedic defects and bone graft
surgeries are increasing in global prevalence. Research to date has advanced the …

The concept of tissue and cell guidance is rapidly evolving as more information regarding
the effect of the microenvironment on cellular function and tissue morphogenesis become …

Shortcomings related to the treatment of bone diseases and consequent tissue regeneration
such as transplants have been addressed to some extent by tissue engineering and …

Highlights•Bone regeneration requires spatiotemporally controlled signals and cells.•No cell-
based therapy is approved to augment bone regeneration.•Controlled drug delivery …

Bone is a dynamic tissue that undergoes significant turnover during the life cycle of an
individual. Despite having a significant regenerative capability, trauma and other …

Limitations of current treatment options for critical size bone defects create a significant
clinical need for tissue engineered bone strategies. This review describes how control over …

Complications in treatment of large bone defects using bone grafting still remain. Our
understanding of the endogenous bone regeneration cascade has inspired the exploration …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

The controlled delivery of growth factors and cells within biomaterial carriers can enhance
and accelerate functional bone formation. The carrier system can be designed with pre …