Sperm-oocyte interplay: an overview of spermatozoon's role in oocyte activation and current perspectives in diagnosis and fertility treatment
MI Zafar, S Lu, H Li - Cell & bioscience, 2021 - Springer
The fertilizing spermatozoon is a highly specialized cell that selects from millions along the
female tract until the oocyte. The paternal components influence the oocyte activation during …
female tract until the oocyte. The paternal components influence the oocyte activation during …
Sperm contributions to oocyte activation: more that meets the eye
It is well known that for successful fertilization, oocyte activation is required, which involves a
signal transduction cascade leading to the conversion of the oocyte to a diploid embryo …
signal transduction cascade leading to the conversion of the oocyte to a diploid embryo …
Sperm factors and oocyte activation: current controversies and considerations
The beginning of embryogenesis is preceded by a sequence of events mediated by the
release of intracellular calcium in the ooplasm, a multifaceted process known as oocyte …
release of intracellular calcium in the ooplasm, a multifaceted process known as oocyte …
Oocyte activation deficiency: a role for an oocyte contribution?
BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
How do spermatozoa activate oocytes?
B Dale, M Wilding, GF Coppola, E Tosti - Reproductive biomedicine online, 2010 - Elsevier
Although the spermatozoon is 500,000 times smaller in volume than the oocyte, it induces
rapid and dramatic changes in oocyte physiology that lead to meiosis re-initiation. These …
rapid and dramatic changes in oocyte physiology that lead to meiosis re-initiation. These …
Oocyte activation: lessons from human infertility
D Ben-Yosef, R Shalgi - Trends in Molecular Medicine, 2001 - cell.com
During fertilization, the spermatozoon penetrates through the cumulus cells and the zona
pellucida that surrounds the oocyte, before it binds and fuses with the oocyte plasma …
pellucida that surrounds the oocyte, before it binds and fuses with the oocyte plasma …
PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis
In mammals, egg activation is initiated by multiple cytosolic Ca2+ transients (Ca2+
oscillations) that are triggered following delivery of a putative sperm factor from the fertilizing …
oscillations) that are triggered following delivery of a putative sperm factor from the fertilizing …
[HTML][HTML] Essential role of sperm-specific PLC-zeta in egg activation and male factor infertility: an update
Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological
stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation …
stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation …
The testicular and epididymal expression profile of PLCζ in mouse and human does not support its role as a sperm-borne oocyte activating factor
Phospholipase C zeta (PLCζ) is a candidate sperm-borne oocyte activating factor (SOAF)
which has recently received attention as a potential biomarker of human male infertility …
which has recently received attention as a potential biomarker of human male infertility …
The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation
At mammalian fertilisation, the fundamental stimulus that triggers oocyte (egg) activation and
initiation of early embryonic development is an acute rise of the intracellular-free calcium …
initiation of early embryonic development is an acute rise of the intracellular-free calcium …