Hyperphosphatemia is a major risk factor for death, CVE, and vascular calcification among
patients with and without kidney disease. Even serum phosphate levels within the “normal …

Phosphate levels are consistently linked with cardiac calcification, cardiovascular disease
(CVD), and death in populations with chronic kidney disease. In addition, mechanistic …

Phosphate is essential for life but its accumulation can be detrimental. In end‐stage renal
disease, widespread vascular calcification occurs as a result of chronic phosphate load. The …

The kidneys excrete excess dietary phosphate, and patients with chronic kidney disease
may suffer from phosphate overload and hyperphosphatemia. In chronic kidney disease …

Abstract Background and Aim: Due to increasing evidence suggesting a link between
hyperphosphatemia and cardiovascular disease (CVD), mediated through vascular …

Chronic kidney disease (CKD) is characterized by high cardiovascular morbidity/mortality,
which is linked in part to vascular calcification (VC) and endothelial dysfunction (ED) …

There is an intimate association between mineral and bone disorders in chronic kidney
disease (CKD) and the extensive burden of cardiovascular disease (CVD) in this population …

Hyperphosphatemia or even serum phosphate levels within the “normal laboratory range”
are highly associated with increased cardiovascular disease risk and mortality in the general …

Dietary habits in the western world lead to increasing phosphate intake. Under physiological
conditions, extraosseous precipitation of phosphate with calcium is prevented by a mineral …

It has already been established that in end-stage renal disease, hyperphosphatemia causes
soft tissue calcification including vascular calcifications. It has also been supported that there …