Tumor metastasis is a major concern in tumor therapy. In our previous studies, a novel tumor
therapeutic modality of the cryo-thermal therapy has been presented, highlighting its effect …

Achieving control of metastatic disease is a long-sought goal in cancer therapy. Treatments
that encourage a patient's own immune system are bringing new hopes in reaching such a …

Recent studies suggest that highly activated, polyfunctional CD4+ T cells are incredibly
effective in strengthening and sustaining overall host antitumor immunity, promoting tumor …

Previous, we established a novel therapeutic approach to tumour of cryo-thermal therapy,
which can induce durable anti-tumour memory immunity mediated by CD4+ T cell, and …

Background Traditional tumor thermal ablations, such as radiofrequency ablation (RFA) and
cryoablation, can result in good local control of tumor, but traditional tumor thermal ablations …

Many cancer therapies are being developed for the induction of durable anti-tumor
immunity, especially for malignant tumors. The activation of antigen-presenting cells (APCs) …

Immunotherapy has emerged as a therapeutic pillar in tumor treatment, but only a minority of
patients get benefit. Overcoming the limitations of immunosuppressive environment is …

Background Strategies that restore the immune system's ability to recognize malignant cells
have yielded clinical benefits but only in some patients. Tumor cells survive cryotherapy and …

Purpose: We previously developed a novel cryo-thermal therapy to treat malignant
mammary carcinoma and melanoma in a mouse model; long-term survival and CD4+ T cell …

Purpose In our previous study, a novel cryo-thermal therapy that could stimulate the
maturation of innate immune cells to subsequently activate the CD4+ Th1 cell-dominated …