Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays

S Amin, D Desai, SS Hecht… - Tobacco-Specific N …, 2017 - api.taylorfrancis.com
Tobacco-specific A-nitrosamines (TSNA) are the most abundant, strong carcino gens in
tobacco smoke. Seven TSNA have been identified in tobacco products: N'-nitrosonornicotine …

Formation of tobacco-specific nitrosamines

B Spiegelhalder, S Fischer - Critical reviews in toxicology, 1991 - Taylor & Francis
Tobacco-specific nitrosamines (TSNA) are by far the most abundant carcinogens found in
tobacco and tobacco smoke. Two of the known TSNA-N'-nitrosonornicotine (NNN) and 4 …

Identification and analysis of a nicotine-derived N-nitrosamino acid and other nitrosamino acids in tobacco

MV Djordjevic, KD Brunnemann, D Hoffmann - Carcinogenesis, 1989 - academic.oup.com
Research on carcinogenic, tobacco-specific N-nitrosamines (TSNA) led to the identification
and analysis of 4-(methyl-iiftrosamino)-4-(3-pyridyl) butyric add (iso-NNAQ in tobacco and …

Formation, Occurrence, and Carcinogenicity of N-Nitrosamines in Tobacco Products

D HOFFMANN, JD ADAMS, KD BRUNNEMANN… - 1981 - ACS Publications
Tobacco and tobacco smoke contain three types of N-nitrosamines. These are the volatile
nitrosamines (VNA), nitrosamines deriving from residues of agricultural chemicals on …

[PDF][PDF] Improved method for the determination of tobacco-specific nitrosamines (TSNA) in tobacco smoke

S Fischer, B Spiegelhalder - Contributions to Tobacco & Nicotine …, 1989 - sciendo.com
The method used to determine tobacco-specific nitcosamines [TSNA], N'-l; l.
itrosonornicotine (NNN], 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [NNK.), N' …

[引用][C] Chemical studies on tobacco smoke: LXXV. Rapid method for the analysis of tobacco-specific N-nitrosamines by gas—liquid chromatography with a thermal …

JD Adams, KD Brunnemann, D Hoffmann - Journal of Chromatography A, 1983 - Elsevier
The occurrence of N'-nitrosonornicotine(NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone(NNK) and N'-nitrosoanatabine(NAT) in tobacco and tobacco smoke has been …

Assessment of tobacco-specific N-nitrosamines in tobacco products

D Hoffmann, JD Adams, KD Brunnemann, SS Hecht - Cancer research, 1979 - AACR
Tobacco-specific nonvolatile N-nitrosamines in tobacco and in fresh mainstream and
sidestream smoke of cigarettes and cigars were quantitatively determined with a thermal …

Tobacco‐specific N‐nitrosamines and ARECA‐derived N‐nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans

D Hoffmann, KD Brunnemann… - Journal of Toxicology …, 1994 - Taylor & Francis
Nicotine and the minor tobacco alkaloids give rise to tobacco‐specific N‐nitrosamines
(TSNA) during tobacco processing and during smoking. Chemical‐analytical studies led to …

Tobacco-specific nitrosamines: A literature review

E Konstantinou, F Fotopoulou, A Drosos… - Food and chemical …, 2018 - Elsevier
Cigarette smoke is a complex mixture of chemicals, including several tobacco-specific
nitrosamines (TSNA). Most TSNA are formed in tobacco during the post-harvest period …

Tobacco specific N-nitrosamines: occurrence and bioassays.

D Hoffmann, JD Adams, KD Brunnemann… - IARC scientific …, 1982 - europepmc.org
A new GC-TEA method for the analysis of tobacco-specific N-nitrosamines (TSNA) has been
developed. Four TSNA have thus far been identified; these are N'-nitrosonornicotine (NNN) …