Sporadic breast cancer develops through the accumulation of molecular abnormalities in
normal breast tissue, resulting from exposure to estrogens and other carcinogens beginning …

Breast cancer is the most common cancer among women, accounting for about 30% of all
cancers. In contrast, breast cancer is a rare disease in men, accounting for less than 1% of …

Somatic changes in the genome of breast cancer cells include amplifications, deletions and
gene mutations. Several chromosome regions harboring known oncogenes are found …

Historical data have indicated the potential for the histologically-normal breast to harbor pre-
malignant changes at the molecular level. We postulated that a histologically-normal tissue …

A number of gene and chromosome alterations have been identified in sporadic breast
carcinomas, and their clinical implications have been investigated. Changes in proto …

Background Genome-wide association studies have identified several breast cancer
susceptibility loci. However, biomarkers for risk assessment are still missing. Here, we …

While the association of a number of risk factors, such as family history and reproductive
patterns, with breast cancer has been well established for many years, work in the past 10 …

Whilst investigators have clearly shown that non-hereditary factors dominate the aetiology of
human breast cancer, they have failed to identify quantitatively important causes, and …

Early pregnancy imprints in the breast permanent genomic changes or a signature that
reduces the susceptibility of this organ to cancer. The breast attains its maximum …

Normal human breast tissue consists of epithelial and nonepithelial cells with different
molecular profiles and differentiation grades. This molecular heterogeneity is known to yield …