Background Genomic analyses of hundreds of prostate tumors have defined a diverse
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …

Prostate cancer is a common malignancy in men, with a markedly variable clinical course.
Somatic alterations in DNA drive the growth of prostate cancers and may underlie the …

Abstract The Androgen Receptor (AR) is the key-driving transcription factor in prostate
cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has …

Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …

DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …

Background Tumor-specific genomic aberrations are routinely determined by high-
throughput genomic measurements. It remains unclear how complex genome alterations …

Half of prostate cancers harbor gene fusions between TMPRSS2 and members of the ETS
transcription factor family. To date, little is known about the presence of non-ETS fusion …

There are remarkable disparities among patients of different races with prostate cancer;
however, the mechanism underlying this difference remains unclear. Here, we present a …

Background and objectives Transcriptomic landscape of prostate cancer (PCa) shows
multidimensional variability, potentially arising from the cell-of-origin, reflected in serum …

Identifying the earliest somatic changes in prostate cancer can give important insights into
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …