A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

H Plovier, A Everard, C Druart, C Depommier… - Nature medicine, 2017 - nature.com
Obesity and type 2 diabetes are associated with low-grade inflammation and specific
changes in gut microbiota composition,,,,,,. We previously demonstrated that administration …

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

C Depommier, A Everard, C Druart, H Plovier… - Nature medicine, 2019 - nature.com
Metabolic syndrome is characterized by a constellation of comorbidities that predispose
individuals to an increased risk of developing cardiovascular pathologies as well as type 2 …

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

A Everard, C Belzer, L Geurts… - Proceedings of the …, 2013 - National Acad Sciences
Obesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and
gut barrier disruption. Microbial composition and the mechanisms of interaction with the host …

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

HS Yoon, CH Cho, MS Yun, SJ Jang, HJ You… - Nature …, 2021 - nature.com
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy
metabolism, glucose tolerance, immune system maturation and function in humans …

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

PD Cani, WM de Vos - Frontiers in microbiology, 2017 - frontiersin.org
Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide
epidemic. Among the different environmental factors, the gut microbiota is now considered …

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

M Schneeberger, A Everard, AG Gómez-Valadés… - Scientific reports, 2015 - nature.com
Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of
obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in …

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

PD Cani, C Depommier, M Derrien, A Everard… - Nature Reviews …, 2022 - nature.com
Ever since Akkermansia muciniphila was discovered and characterized two decades ago,
numerous studies have shown that the lack or decreased abundance of this commensal …

Akkermansia muciniphila: is it the Holy Grail for ameliorating metabolic diseases?

J Yan, L Sheng, H Li - Gut Microbes, 2021 - Taylor & Francis
The increasing prevalence of metabolic diseases has become a severe public health
problem. Gut microbiota play important roles in maintaining human health by modulating the …

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Y Xu, N Wang, HY Tan, S Li, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a
worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has …

Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium

J Si, H Kang, HJ You, GP Ko - Gut Microbes, 2022 - Taylor & Francis
Despite a short history since its first isolation, Akkermansia muciniphila has been extensively
studied in relation to its effects on human metabolism. A recent human intervention study …