Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)
E Abati, N Bresolin, G Comi, S Corti - Expert opinion on therapeutic …, 2020 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and incurable
neurodegenerative disorder that targets upper and lower motor neurons and leads to fatal …
neurodegenerative disorder that targets upper and lower motor neurons and leads to fatal …
Silencing strategies for therapy of SOD1-mediated ALS
B van Zundert, RH Brown Jr - Neuroscience Letters, 2017 - Elsevier
Amyotrophic lateral sclerosis (ALS) is an adult-onset, lethal, paralytic disorder caused by the
degeneration of motor neurons. Our understanding of this disease has been greatly …
degeneration of motor neurons. Our understanding of this disease has been greatly …
SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice
E Dirren, J Aebischer, C Rochat… - Annals of clinical …, 2015 - Wiley Online Library
Objective Amyotrophic lateral sclerosis is an incurable disorder mainly characterized by
motoneuron degeneration. Mutations in the superoxide dismutase 1 (SOD 1) gene account …
motoneuron degeneration. Mutations in the superoxide dismutase 1 (SOD 1) gene account …
Translating SOD1 gene silencing toward the clinic: a highly efficacious, off-target-free, and biomarker-supported strategy for fALS
T Iannitti, JM Scarrott, S Likhite, IRP Coldicott… - … Therapy-Nucleic Acids, 2018 - cell.com
Of familial amyotrophic lateral sclerosis (fALS) cases, 20% are caused by mutations in the
gene encoding human cytosolic Cu/Zn superoxide dismutase (hSOD1). Efficient translation …
gene encoding human cytosolic Cu/Zn superoxide dismutase (hSOD1). Efficient translation …
Safe and effective superoxide dismutase 1 silencing using artificial microRNA in macaques
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease caused by degeneration
of motor neurons leading to rapidly progressive paralysis. About 10% of cases are caused …
of motor neurons leading to rapidly progressive paralysis. About 10% of cases are caused …
A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo …
MMJ Da Costa, CE Allen… - Disease models & …, 2014 - journals.biologists.com
Mutations in the superoxide dismutase gene (SOD1) are one cause of familial amyotrophic
lateral sclerosis [ALS; also known as motor neuron disease (MND)] in humans. ALS is a …
lateral sclerosis [ALS; also known as motor neuron disease (MND)] in humans. ALS is a …
RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells
MM Maxwell, P Pasinelli… - Proceedings of the …, 2004 - National Acad Sciences
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disorder
resulting from selective death of motor neurons in the brain and spinal cord. In≈ 25% of …
resulting from selective death of motor neurons in the brain and spinal cord. In≈ 25% of …
Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration
BM Morrison, JH Morrison - Brain research reviews, 1999 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating neurologic disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. Until …
progresses from mild motor symptoms to severe motor paralysis and premature death. Until …
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
GS Ralph, PA Radcliffe, DM Day, JM Carthy… - Nature medicine, 2005 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in the
selective death of motor neurons in the brain and spinal cord. Some familial cases of ALS …
selective death of motor neurons in the brain and spinal cord. Some familial cases of ALS …
A new AAV10-U7-mediated gene therapy prolongs survival and restores function in an ALS mouse model
MG Biferi, M Cohen-Tannoudji, A Cappelletto… - Molecular Therapy, 2017 - cell.com
One of the most promising therapeutic approaches for familial amyotrophic lateral sclerosis
linked to superoxide dismutase 1 (SOD1) is the suppression of toxic mutant SOD1 in the …
linked to superoxide dismutase 1 (SOD1) is the suppression of toxic mutant SOD1 in the …