Neural differentiation from human embryonic stem cells (hESCs) provides a promising
source for cell replacement therapies. However, the mechanisms underlying the control of …

Background Sox2 is a well-established pluripotent transcription factor that plays an essential
role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a …

The transcription factor Sox2 is expressed at high levels in neural stem and progenitor cells.
Here, we inactivated Sox2 specifically in the developing brain by using Cre–loxP system …

Pluripotent embryonic stem (ES) cells can generate all cell types, but how cell lineages are
initially specified and maintained during development remains largely unknown. Different …

Embryonic stem cells (ESCs) are pluripotent and self-renewing cells that are derived from
the inner cell mass (ICM) of the developing blastocysts (Evans and Kaufman, 1981; Martin …

SOX2 and SOX15 are Sox family transcription factors enriched in embryonic stem cells
(ESCs). The role of SOX2 in activating gene expression programs essential for stem cell self …

Throughout the vertebrate evolution, Sox2 marks the developing nervous system from its
earliest developmental stages and, therein, the most undifferentiated precursor cells …

The essential role of SOX2 in embryogenesis was first demonstrated by the Sox2 gene
knockout in mouse, leading to early embryonic lethality by loss of the epiblast, the founder …

The aims of this PhD research were: to examine molecular mechanisms underlying the
transcriptional regulation of the Sox2 gene during forebrain development; to examine the …

Neural crest (NC) cells give rise to a wide variety of cell types and tissues, such as neurons
and glial cells in the peripheral nervous system. Sox2, which encodes an HMG‐box …