Background Tanjin is an herbal medicine made from the root of salvia miltiorrhiza. It is
predominantly given to arteriosclerotic patients as a supplement to ameliorate the clinical …

Objective To study the effect of Danshen on the pharmacokinetics of Rosuvastatin in rats.
Methods Parallel control method was applied in this study. Twelve male rats weighing …

The aim of this study was to explore potential herb–drug interaction between danshensu or
ursolic acid and rosuvastatin. Compared to the control group given rosuvastatin alone, the …

Background: We assumed that the pharmacokinetics of lovastatin could be changed by the
induction effect of berberine. Methods: An UPLC-MS/MS method was developed and …

Objectives To evaluate the effect of silymarin on the pharmacokinetics of rosuvastatin in
systems overexpressing OATP1B1 or BCRP transporters and in healthy subjects. Materials …

The study was designed to explore the drug-drug interactions mechanisms mediated by
OATP1B1 between traditional Chinese medicine Danshensu and rosuvastatin. First, the …

Atorvastatin, an effective lipid-lowering drug, could reduce the risks of morbidity and
mortality of cardiovascular diseases. Patients with cardiovascular diseases often use …

Background: Green tea can inhibit OATPs, so it may interact with the substrate of OATPs,
such as rosuvastatin. Objective: This study aimed to investigate the effects of green tea on …

In this report, we investigated the hepatocytic uptake of rosuvastatin when administered with
scutellarin (a Chinese herbal medicine) in rats and the role of organic anion transporting …

The purpose of this study was to investigate the potential pharmacokinetic interactions with
natural products (such as piperine (PIP), gallic acid (GA) and cinnamic acid (CA)) and …