Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons
are now recognized as a central pathway responsible for conveying key homeostatic …

The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction
and is essential for the initiation of human puberty and maintenance of adult reproduction …

Kisspeptin binding to its G-protein-coupled receptor KISS1R (also known as GPR54), which
is expressed by gonadotropin-releasing hormone (GnRH) neurons, stimulates GnRH …

Body energy reserves and metabolic state are relevant modifiers of puberty onset and
fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid …

Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis,
but the molecular and cellular mechanisms by which hormonal and environmental signals …

Unraveling of the master role of kisspeptins, the products of the KiSS-1 gene, and their
receptor, GPR54, in the control of reproduction has been a major breakthrough in …

Kisspeptins, a family of peptides encoded by the KISS1 gene which binds GPR54 (or KISS1
receptor), have recently emerged as essential neuropeptide regulators of key aspects of …