Abstract Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription,
implicated in the development of heart failure. CaMKII-dependent phosphorylation drives …

Cardiac hypertrophy and heart failure (HF) are associated with reactivation of fetal cardiac
genes, and class II histone deacetylases (HDACs)(eg, HDAC5) have been strongly …

Abstract Class IIa histone deacetylases (HDACs) critically regulate cardiac function through
the repression of the activity of myocyte enhancer factor 2 (MEF2)-dependent gene …

Class IIa histone deacetylases (HDACs) regulate a variety of cellular processes, including
cardiac growth, bone development, and specification of skeletal muscle fiber type. Multiple …

Histone deacetylase 4 (HDAC4) regulates numerous gene expression programs through its
signal-dependent repression of myocyte enhancer factor 2 (MEF2) and serum response …

Abstract Class IIa histone deacetylases (HDACs) are transcriptional repressors whose
nuclear export in the cardiac myocyte is associated with the induction of pathological gene …

Abstract Background Persistent cardiac Ca 2+/calmodulin dependent Kinase II (CaMKII)
activation plays an essential role in heart failure development. However, the molecular …

Class II histone deacetylases (HDACs) act as repressors of cardiac hypertrophy, an
adaptative response of the heart characterized by a reprogramming of fetal cardiac genes …

Background Class II a histone deacetylase (HDAC) isoforms such as HDAC 5 are critical
signal‐responsive repressors of maladaptive cardiomyocyte hypertrophy, through nuclear …

Dynamic nucleocytoplasmic shuttling of class IIa histone deacetylases (HDACs) is a
fundamental mechanism regulating gene transcription. Recent studies have identified …