Diabetes mellitus is a growing worldwide epidemic disease, currently affecting 1 in 12
adults. Treatment of disease complications typically consumes∼ 10% of healthcare budgets …

When diabetes is diagnosed, the majority of insulin-secreting pancreatic β cells are already
dysfunctional or destroyed. This β cell dysfunction/destruction usually takes place over many …

Previously, studies of the endocrine pancreatic β-cell were mainly performed ex vivo by
morphological means. This data supported the analyis of pathophysiological changes in the …

Diabetes mellitus results in impaired insulin production by pancreatic beta-cells due to their
death and/or dysfunction. There is a growing unmet need among diabetes researches and …

A common feature in the pathophysiology of different types of diabetes is the reduction of β
cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 …

Systems biology is an emergent field that aims to understand biological systems at system-
level. The increasing power of genome sequencing techniques and ranges of other …

Aims To investigate whether manganese‐enhanced magnetic resonance imaging can
assess functional pancreatic beta‐cell mass in people with type 1 diabetes mellitus …

The increasing incidence of diabetes requires a better understanding of the pathogenesis of
the clinical disease. Studies in prevention and treatment have been hampered by the single …

The prevalence of diabetes is 382 million worldwide, and is expected to rise to 592 million in
2035 (http://www. idf. org/diabetesatlas); 2.5–15% of national annual healthcare budgets are …

Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …