Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are
associated with dysbiosis of the gut microbiome. Emerging evidence suggests that small …

The gut microbiota is a crucial actor in human physiology. Many of these effects are
mediated by metabolites that are either produced by the microbes or derived from the …

In a complex, diverse intestinal environment, commensal microbiota metabolizes excessive
dietary tryptophan to produce more bioactive metabolites connecting with kinds of diverse …

The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …

Tryptophan (Trp) is an essential amino acid primarily derived from the diet for use by the
host for protein synthesis. The intestinal tract is lined with cells, both host and microbial, that …

The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …

We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon
receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low …

Commensal microbiota-dependent tryptophan catabolism within the gastrointestinal tract is
known to exert profound effects upon host physiology, including the maintenance of …

The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis,
and different immune, hormonal, and neuronal signals participate to this interkingdom …