Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Abstract Background Kisspeptins, encoded by Kiss1, have emerged as essential regulators
of puberty and reproduction by primarily acting on GnRH neurons, via their canonical …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …

The Kiss1 gene encodes a family of peptides called kisspeptins, which bind to the G protein-
coupled receptor GPR54. Kisspeptin (s) and its receptor are expressed in the forebrain, and …

The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing
hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons …

Kisspeptin binding to its G-protein-coupled receptor KISS1R (also known as GPR54), which
is expressed by gonadotropin-releasing hormone (GnRH) neurons, stimulates GnRH …

Kisspeptin was initially identified as a metastasis suppressor. Shortly after the initial
discovery, a key physiologic role for kisspeptin emerged in the regulation of fertility, with …

Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons
are now recognized as a central pathway responsible for conveying key homeostatic …

The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …