The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

BACKGROUND Kisspeptins, and their cognate receptor gpr-54, were first found to regulate
the hypothalamic–pituitary–gonadal (HPG) axis in 2003, when two groups demonstrated …

The neuropeptide kisspeptin and its G‐protein‐coupled receptor, Gpr54, are critical
regulators of fertility. Two major populations of kisspeptin neurones exist in the rodent: one …

Kisspeptins, a family of neuropeptides encoded by the Kiss1 gene that are mainly expressed
in discrete neuronal populations of the hypothalamus, have recently emerged as essential …

Kisspeptin cells appear to be the “missing link,” bridging the divide between levels of
gonadal steroids and feedback control of gonadotropin-releasing hormone (GnRH) …

Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in
the neural control of fertility in animal models and humans. The gonadotropin-releasing …

Unraveling of the master role of kisspeptins, the products of the KiSS-1 gene, and their
receptor, GPR54, in the control of reproduction has been a major breakthrough in …

Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common
pathway by which the brain regulates reproduction. GnRH neurons are regulated by an …

GnRH neurons play a pivotal role in the central regulation of fertility. Kisspeptin greatly
increases GnRH/LH release and GnRH neuron firing activity and may be involved in …

Background Kisspeptin and its G protein-coupled receptor (GPR) 54 are essential for
activation of the hypothalamo-pituitary-gonadal axis. In the rat, the kisspeptin neurons critical …