The discovery that kisspeptin was critical for normal fertility in humans ushered in a new
chapter in our understanding of the control of GnRH secretion. In this paper, we will review …

While kisspeptin was initially found to function as a metastasis suppressor, after
identification of its receptor KISS1R and their expression profiles in tissues such as the …

Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction
and is essential for the initiation of human puberty and maintenance of adult reproduction …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

The neuropeptide kisspeptin is a potent stimulator of GnRH neurons and has been
implicated as a major regulator of the hypothalamus-pituitary-gonadal axis. There are mainly …

The hypothalamic hormone GnRH is a central driver of pituitary gonadotropin secretion,
controlling pulsatile gonadotropin secretion, modulating gonadal steroid feedback, and …

Body energy reserves and metabolic state are relevant modifiers of puberty onset and
fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of
reproductive functions in mammals owing to its involvement in the direct activation of …

Recent, compelling evidence indicates that kisspeptins, the products of KiSS‐1 gene, and
their receptor GPR54, represent key elements in the neuroendocrine control of reproduction …