Kisspeptin signaling via the kisspeptin receptor G‐protein‐coupled receptor‐54 plays a
fundamental role in the onset of puberty and the regulation of mammalian reproduction. In …

It is well established that reproductive function is gated by the state of energy reserves of the
organism; conditions of metabolic stress and energy insufficiency being frequently coupled …

The hypothalamo‐pituitary‐gonadal (HPG) axis is the regulatory system for reproduction in
mammals. Because secretion of gonadotropin‐releasing hormone (GnRH) into the portal …

Kisspeptins, a family of peptides encoded by the KISS1 gene which binds GPR54 (or KISS1
receptor), have recently emerged as essential neuropeptide regulators of key aspects of …

Kisspeptin has been recognized as a key regulator of GnRH secretion during puberty and
adulthood, conveying the feedback influence of endogenous gonadal steroids onto the …

Hypogonadism occurs commonly in men with type 2 diabetes (T2DM) and severe obesity.
Current evidence points to a decreased secretion of gonadotropin-releasing hormone …

The KiSS-1 gene codes for a family of neuropeptides called kisspeptins which bind to the G-
protein-coupled receptor GPR54. To assess the possible effects of kisspeptins on …

Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that
regulate the mammalian reproductive axis by a central action in the hypothalamus to …

The recent identification of loss-of-function mutations in the gene encoding GPR54, the
receptor for the KiSS-1-derived peptides, kisspeptins, has highlighted a previously …

The kisspeptin precursor is the protein transcribed from the Kiss-1 gene and the kisspeptins
are the peptides that are posttranslationally processed from the precursor. The kisspeptins …