Kisspeptin (encoded by KISS1) is a crucial activator of reproductive function. The role of
kisspeptin has been studied extensively within the hypothalamus but little is known about its …

The Kiss1 gene encodes a family of peptides called kisspeptins, which are the natural
ligands for the receptor GPR54. In humans and mice, inactivating mutations of GPR54 …

The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the
neuroendocrine-reproductive axis in mammals. During the last decade, major advances …

It is well established that reproductive function is metabolically gated. However, the
mechanisms whereby energy stores and metabolic cues influence fertility are yet to be …

Kisspeptins are a group of peptide fragments encoded by the KISS1 gene in humans. They
bind to kisspeptin receptors with equal efficacy. Kisspeptins and their receptors are …

Kisspeptin, encoded by the Kiss1 gene, has attracted attention as a key candidate
neuropeptide in controlling puberty and reproduction via regulation of gonadotrophin …

The Kiss1 gene codes for kisspeptin, which binds to GPR54, a G-protein-coupled receptor.
Kisspeptin and GPR54 are expressed in discrete regions of the forebrain, and they have …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural
ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among …

Background Kisspeptin is the leading upstream regulator of pulsatile and surge
Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as …