Context: Reproduction in all mammals is controlled by a hypothalamic clock that produces
periodic secretory pulses of GnRH, but how the timing of these pulses is determined is …

Kisspeptin–GPR54 signaling in the hypothalamus is required for reproduction and fertility in
mammals. Kiss1 neurons are key regulators of gonadotropin-releasing hormone (GnRH) …

The status of the neuroendocrine reproductive axis differs dramatically during various stages
of development, and also differs in several critical ways between the sexes, including its …

Kisspeptin and its cognate receptor, GPR54, are critical for reproductive development and
for the regulation of gonadotropin-releasing hormone (GnRH) secretion. Although kisspeptin …

The neuropeptide kisspeptin is necessary for reproduction, fertility, and puberty. Here, we
show strong kisspeptin innervation of hypothalamic anorexigenic proopiomelanocortin …

Kisspeptin-Gpr54 signaling is critical for the GnRH neuronal network controlling fertility. The
present study reports on a kisspeptin (Kiss)-green fluorescent protein (GFP) mouse model …

We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54,
in governing the onset of puberty in the mouse. In the adult male and female mouse …

Kisspeptins are a group of peptides that stimulate GnRH release and are required for
puberty and maintenance of normal reproductive function. This review focuses on our …

The neuropeptide kisspeptin has recently been implicated as having a critical role in the
activation of the GnRH neurons to bring about puberty. We examined here the postnatal …

Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet,
whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of …