Kisspeptin‐GPR54 signalling is essential for normal reproductive functioning. However, the
distribution of kisspeptin neuronal cell bodies and their projections is not well established …

Last year, a little known G protein-coupled receptor, GPR54, was unexpectedly catapulted to
a key regulatory position within the hypothalamic-pituitary-gonadal axis. Several lines of …

Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis,
but the molecular and cellular mechanisms by which hormonal and environmental signals …

Studies undertaken in many species indicate that kisspeptin–Gpr54 signaling is essential for
the activation of gonadotropin-releasing hormone (GnRH) neurons to bring about puberty …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

Kisspeptins, which are products of the Kiss1 gene, and their receptor, GPR54, have
emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) …

Kisspeptins, encoded by the Kiss1 gene, and their canonical receptor, GPR54 (also termed
Kiss1R), are unanimously recognised as essential regulators of puberty onset and …

Landmark studies have shown that mutations in kisspeptin and the kisspeptin receptor
(Kiss1r) result in reproductive dysfunction in humans and genetically altered mouse models …

Since the stimulatory effect of kisspeptin on gonadotropin secretion is blocked by a GnRH
antagonist, it has been suggested that the effect of kisspeptin is manifest exclusively at the …

Reproductive maturation and function are maintained by a complex neurohormonal network
that integrates at the so-called hypothalamic–pituitary–gonadal (HPG) axis. This system is …