The conditioned place preference paradigm is a standard preclinical behavioral model used
to study the rewarding and aversive effects of drugs. Although a number of different designs …

Alcohol has been reported to modulate the reinforcing and aversive properties of cocaine.
Given these effects, the present study examined whether this interaction could be extended …

Previous studies have implicated the tegmental pedunculopontine (TPP) nucleus in
mediating the rewarding effects of opiates, food, and amphetamine, provided that animals …

Relapse is a serious problem for the effective treatment of cocaine addiction. RATIONALE:
Examining cocaine re-exposure-induced behavioral and neurobiological alterations …

Conditioned place preference (CPP) is a widely used model of addiction-related behavior
whose underlying mechanisms are not understood. In this study, we used dual site silicon …

Psychosocial and environmental factors, including loss of natural reward, contribute to the
risk of drug abuse. Reward loss has been modeled in animals by removal from social or …

Endogenous opioids have been implicated in cocaine reward. However, the role of each
opioid peptide in this regard is unknown. Notably, the role of each peptide in extinction and …

Rationale Age of initial exposure to addictive substances is inversely proportional to risk of
developing drug dependence. There is debate, however, as to whether intake at a young …

The identification of behavioral traits that could predict an individual's susceptibility to
engage in cocaine addiction is relevant for understanding and preventing this disorder, but …

Rationale Dopamine may produce reward-related learning by activating D 1-like receptors
in the nucleus accumbens (NAc) and stimulating the formation of cyclic adenosine …