[HTML][HTML] Vaccine protection against the SARS-CoV-2 Omicron variant in macaques

A Chandrashekar, J Yu, K McMahan, C Jacob-Dolan… - Cell, 2022 - cell.com
The rapid spread of the SARS-CoV-2 Omicron (B. 1.1. 529) variant, including in highly
vaccinated populations, has raised important questions about the efficacy of current …

[HTML][HTML] Booster with Ad26. COV2. S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques

L Solforosi, LMM Costes, JTBM Tolboom… - Nature …, 2023 - nature.com
Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-
19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously …

[HTML][HTML] Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA. 1 following homologous and heterologous CoronaVac or BNT162b2 vaccination

SMS Cheng, CKP Mok, YWY Leung, SS Ng… - Nature medicine, 2022 - nature.com
The Omicron variant is rapidly becoming the dominant SARS-CoV-2 virus circulating
globally. It is important to define reductions in virus neutralizing activity in the serum of …

[HTML][HTML] mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

VV Edara, KE Manning, M Ellis, L Lai, KM Moore… - Cell Reports …, 2022 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant
emerged in November 2021 and consists of several mutations within the spike. We use …

[HTML][HTML] Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants

Q Wang, C Yang, L Yin, J Sun, W Wang, H Li… - … and Targeted Therapy, 2023 - nature.com
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the
effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains …

[HTML][HTML] T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals

V Naranbhai, A Nathan, C Kaseke, C Berrios, A Khatri… - Cell, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant (B. 1.1. 529) contains mutations that mediate
escape from antibody responses, although the extent to which these substitutions in spike …

[HTML][HTML] Real-world COVID-19 vaccine effectiveness against the Omicron BA. 2 variant in a SARS-CoV-2 infection-naive population

JJ Lau, SMS Cheng, K Leung, CK Lee, A Hachim… - Nature medicine, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant has demonstrated enhanced transmissibility and
escape of vaccine-derived immunity. Although first-generation vaccines remain effective …

[HTML][HTML] Third BNT162b2 vaccination neutralization of SARS-CoV-2 Omicron infection

I Nemet, L Kliker, Y Lustig, N Zuckerman… - … England Journal of …, 2022 - Mass Medical Soc
Neutralization of Omicron with Third Vaccine Dose Serum samples from 20 participants who
had received two doses of the BNT162b2 vaccine and from 20 who had received three …

[HTML][HTML] Updated vaccine protects against SARS-CoV-2 variants including Omicron (B. 1.1. 529) and prevents transmission in hamsters

S Sharma, T Vercruysse, L Sanchez-Felipe… - Nature …, 2022 - nature.com
Current COVID-19 vaccines are based on prototypic spike sequences from ancestral 2019
SARS-CoV-2 strains. However, the ongoing pandemic is fueled by variants of concern …

[HTML][HTML] Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters

K McMahan, V Giffin, LH Tostanoski, B Chung… - Med, 2022 - cell.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
(B. 1.1. 529) variant has proven to be highly transmissible and has outcompeted the Delta …