Hypoxia-inducible factors (HIF) are a family of heterodimeric transcriptional regulators that
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …

The hypoxia-inducible factor 1 (HIF-1) transcriptional complex is regulated by cellular
oxygen levels and growth factors. The phosphoinosotide 3-kinase (PI-3K)-Akt/protein kinase …

Hypoxia is a pervasive microenvironmental factor that affects normal development as well as
tumor progression. In most normal cells, hypoxia stabilizes hypoxia-inducible transcription …

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that mediates the
adaptive responses to hypoxia by effecting the transcription of numerous hypoxia-inducible …

Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response
to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low …

AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic
adaptations under the ATP-deprived conditions such as hypoxia. In the present study, we …

Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that
enable cells to adapt to reduced O2 availability. Proteins encoded by HIF-1 target genes …

Oxygen availability is crucial for cellular metabolism. Hypoxia-inducible factor 1 (HIF-1) is
the major oxygen homeostasis regulator. Under normoxic conditions, HIF-1 is rapidly …

Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the
cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia …

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling
pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive …